Invention Grant
US07700728B2 Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
失效
在筛选测定中使用嵌合受体鉴定细胞受体的激动剂和拮抗剂
- Patent Title: Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
- Patent Title (中): 在筛选测定中使用嵌合受体鉴定细胞受体的激动剂和拮抗剂
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Application No.: US11388884Application Date: 2006-03-24
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Publication No.: US07700728B2Publication Date: 2010-04-20
- Inventor: Elizabeth Esther Mary Bates , Estelle Merck , Odette de Bouteiller , Christophe Caux
- Applicant: Elizabeth Esther Mary Bates , Estelle Merck , Odette de Bouteiller , Christophe Caux
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/16
Abstract:
The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an intracellular immunoreceptor tyrosine-based activation motif (ITAM).
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