发明授权
- 专利标题： Exendins and exendin agonists modified with polyamino acids
- 专利标题（中）： 用聚氨基酸改性的毒蜥外泌肽和毒蜥外泌肽激动剂
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申请号： US12101818申请日： 2008-04-11
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公开(公告)号： US07691963B2公开(公告)日： 2010-04-06
- 发明人: Kathryn S. Prickett , Andrew A. Young
- 申请人： Kathryn S. Prickett , Andrew A. Young
- 申请人地址： US CA San Diego
- 专利权人： Amylin Pharmaceuticals, Inc.
- 当前专利权人： Amylin Pharmaceuticals, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Connolly Bove Lodge & Hutz LLP
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; A61K38/22 ; A61K38/00
摘要：
Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions comprising the modified exendin or the agonist thereof are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
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