发明授权
US07648709B2 Allergy vaccine composition, production method thereof and use of same in allergy treatment
有权
过敏疫苗组合物及其生产方法及其在过敏治疗中的应用
- 专利标题： Allergy vaccine composition, production method thereof and use of same in allergy treatment
- 专利标题（中）： 过敏疫苗组合物及其生产方法及其在过敏治疗中的应用
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申请号： US10513493申请日： 2003-05-08
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公开(公告)号： US07648709B2公开(公告)日： 2010-01-19
- 发明人: Miriam de San Juan Bosco Lastre González , Oliver Germán Pérez Martín , Alexis Labrada Rosado , Igor Bidot Martínez , Gustavo Rafael Bracho Granado , Judith Mónica Del Campo Alonso , Dainerys Aleida Pérez Lastre , Elisa Facenda Ramos , Caridad Zayas Vignier , Claudio Rodríguez Martínez , Victoriano Gustavo Sierra González , Jorge Ernesto Pérez Lastre
- 申请人： Miriam de San Juan Bosco Lastre González , Oliver Germán Pérez Martín , Alexis Labrada Rosado , Igor Bidot Martínez , Gustavo Rafael Bracho Granado , Judith Mónica Del Campo Alonso , Dainerys Aleida Pérez Lastre , Elisa Facenda Ramos , Caridad Zayas Vignier , Claudio Rodríguez Martínez , Victoriano Gustavo Sierra González , Jorge Ernesto Pérez Lastre
- 代理机构： Lackenbach Siegel, LLP
- 优先权： CU91/02 20020508
- 国际申请： PCT/CU03/00007 WO 20030508
- 国际公布： WO03/094964 WO 20031120
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; A61K39/35
摘要：
The present invention relates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.
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