Invention Grant
- Patent Title: O-acyloxime derivatives, preparation method thereof, and pharmaceutical composition containing the same for prevention and treatment of cardiovascular disease
- Patent Title (中): O-酰肟衍生物，其制备方法和含有该组合物的预防和治疗心血管疾病的药物组合物
-
Application No.: US11163383Application Date: 2005-10-17
-
Publication No.: US07642291B2Publication Date: 2010-01-05
- Inventor: Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
- Applicant: Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2004-0092263 20041112
- Main IPC: A61K31/15
- IPC: A61K31/15 ; C07C251/68
Abstract:
The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.
Public/Granted literature
Information query
