发明授权
- 专利标题: Compounds
- 专利标题(中): 化合物
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申请号: US11152777申请日: 2005-06-15
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公开(公告)号: US07553849B2公开(公告)日: 2009-06-30
- 发明人: Anders Björk , Karl Jansson
- 申请人: Anders Björk , Karl Jansson
- 申请人地址: SE Lund
- 专利权人: Active Biotech AB
- 当前专利权人: Active Biotech AB
- 当前专利权人地址: SE Lund
- 代理机构: Browdy and Neimark, P.L.L.C.
- 优先权: SE0401578 20040618
- 主分类号: A61K31/4365
- IPC分类号: A61K31/4365 ; C07D495/06
摘要:
A compound of formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R′ is hydrogen, C1-C4 alkyl, C1-C3 alkoxy; halogen, trifluoromethyl or OCHxFy, R″ is hydrogen, fluoro or chloro, that R″ being fluoro or chloro only when R′ is fluoro or chloro; R3 is hydrogen or C1-C5 alkyl R4 is hydrogen, CH2OCOC(CH3)3, pharmaceutically acceptable inorganic or organic cations, or COR4′ wherein R4′ is C1-C5 alkyl, phenyl, benzyl or phenethyl; R7 is methyl or ethyl; one of A and B is sulphur and the other is C-R2; when A is S, R2 is selected from hydrogen and methyl, with the proviso that R2 is methyl only when R3 is not hydrogen; and when B is S, R2 is hydrogen; and any tautomer thereof. A pharmaceutical composition comprising a compound of formula (I), a method of treating malignant tumours or diseases resulting from autoimmunity or pathologic inflammation.
公开/授权文献
- US20060004038A1 Novel compounds 公开/授权日:2006-01-05
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