A binding device for a wheeled vehicle includes a drive mechanism including a shaft tube, a driven member secured to the shaft tube, at least one driving pawl mounted on the driven member, and a drive member rotatably mounted on the driven member and having an inner wall formed with a plurality of locking grooves engaged with the driving pawl. Thus, the drive member drives the shaft tube to rotate in one direction and performs an idle rotation in the opposite direction, so that the shaft tube is rotatable successively to wind the binding strap successively so as to tighten the cargo without having to remove the drive rod from the drive member, thereby facilitating a user winding the binding strap, and thereby saving the working time and energy.