A multi-function travel case includes a plurality of features for facilitating ease of travel, including a retractable document sleeve for storing important travel-related documents in a manner that allows for quick, secure and easy access, viewing and storage of same during travel. The travel case further includes a retractable bottle holder extendable from a side pocket thereof, a side storage compartment adapted for storing eyeglasses in a manner that prevents scratching of same, a front interior storage compartment that houses a retractable light source, a key holder, and integrated pockets adapted for the storage of optical media without scratching the same, a central interior storage compartment having an adjustable top restraint and first and second user-positionable, impact resistant, adjustable cushions for securing portable computer devices of different sizes, a rear interior storage compartment having a removable file folder housed therein, ergonomically-designed rubber handles, and anti-tip feet.