Invention Grant
- Patent Title: 7-imino derivatives of camptothecin having antitumor activity
- Patent Title (中): 具有抗肿瘤活性的喜树碱的7-亚氨基衍生物
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Application No.: US10546211Application Date: 2004-03-10
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Publication No.: US07351714B2Publication Date: 2008-04-01
- Inventor: Sabrina Dallavalle , Sergio Penco , Claudio Pisano , Franco Zunino
- Applicant: Sabrina Dallavalle , Sergio Penco , Claudio Pisano , Franco Zunino
- Applicant Address: IT Rome IT Milan
- Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.,Istituto Nazionale per Lo Studio E La Cura Dei Tumori
- Current Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.,Istituto Nazionale per Lo Studio E La Cura Dei Tumori
- Current Assignee Address: IT Rome IT Milan
- Agency: Nixon & Vanderhye P.C.
- International Application: PCT/IT2004/000118 WO 20040310
- International Announcement: WO2004/083214 WO 20040930
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D491/22
Abstract:
Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index.Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
Public/Granted literature
- US20060167033A1 7-Imino derivatives of camptothecin having antitumor activity Public/Granted day:2006-07-27
Information query
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