发明授权
US06844148B1 Alzheimer's disease secretase, APP substrates therefor, and uses therefor
失效
阿尔茨海默病分泌酶，APP底物及其用途
- 专利标题： Alzheimer's disease secretase, APP substrates therefor, and uses therefor
- 专利标题（中）： 阿尔茨海默病分泌酶，APP底物及其用途
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申请号： US09668314申请日： 2000-09-22
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公开(公告)号： US06844148B1公开(公告)日： 2005-01-18
- 发明人: Mark Gurney , Michael Jerome Bienkowski
- 申请人： Mark Gurney , Michael Jerome Bienkowski
- 申请人地址： US MI Kalamazoo
- 专利权人： Pharmacia & Upjohn Company
- 当前专利权人： Pharmacia & Upjohn Company
- 当前专利权人地址： US MI Kalamazoo
- 代理机构： Pharmacia & Upjohn Company
- 代理商 Thomas A. Wootton
- 主分类号： A61P25/28
- IPC分类号： A61P25/28 ; C07K14/47 ; C12N1/21 ; C12N9/64 ; C12N15/57 ; C12Q1/37 ; C12Q1/00 ; C07K14/00 ; C12Q1/25
摘要：
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the α-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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