Invention Grant
US06641814B1 Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
失效
衍生自结核分枝杆菌的核酸片段和多肽片段
- Patent Title: Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
- Patent Title (中): 衍生自结核分枝杆菌的核酸片段和多肽片段
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Application No.: US09050739Application Date: 1998-03-30
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Publication No.: US06641814B1Publication Date: 2003-11-04
- Inventor: Peter Andersen , Rikke Nielsen , Thomas Oettinger , Peter Birk Rasmussen , Ida Rosenkrands , Karin Weldingh , Walter Florio
- Applicant: Peter Andersen , Rikke Nielsen , Thomas Oettinger , Peter Birk Rasmussen , Ida Rosenkrands , Karin Weldingh , Walter Florio
- Priority: DK0376/97 19970402
- Main IPC: A61K3902
- IPC: A61K3902
Abstract:
The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153, and 168-171). The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides. Another part of the invention is based on the surprising discovery that fusions between ESAT-6 and MPT59 are superior immunogens compared to each of the unfused proteins, respectively.
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