Invention Grant
- Patent Title: Mono- or polyenic carboxylic acid derivatives
- Patent Title (中): 单或多元羧酸衍生物
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Application No.: US09598420Application Date: 2000-06-20
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Publication No.: US06420363B1Publication Date: 2002-07-16
- Inventor: Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- Applicant: Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- Priority: JP6-267287 19941031; JP7-166120 19950630
- Main IPC: A61K31535
- IPC: A61K31535
Abstract:
To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof: Z—(CR3═CR2)n—COOR1 (1-I) Compounds represented by the general formula (2-I) or physiologically acceptable salts thereof: The compounds according to the present invention exhibit extremely high ability to bind RARs and are effective for treating various kind of diseases such as abnormality in cornification and rheumatoid arthritis.
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