A liposomal vesicular preparation with good encapsulation efficiency for active ingredients, based on homogeneous unilamellar liposomal vesicular lipids, has a substantially tightly packed vesicular structure and forms carriers of active ingredients. At least 20% by weight relative to the total weight of the liposomal vesicular preparation of the active ingredient (drug substances, vaccines, diagnostics, vectors) are present in encapsulated form inside the homogeneous unilamellar liposomal vesicular lipids. The liposomal vesicular preparation is a semi-solid liposomal vesicular lipid gel. The membrane forming amphiphiles can be members of from the group consisting of lipids, phospholipids and synthetic amphiphiles.