An exhaust pipe layout structure for vehicles comprises a first exhaust pipe extending from an exhaust manifold coupled to a rear side of a cylinder head of an engine toward the rear of a vehicle body, a second exhaust pipe and a catalyzer which are connected to each other with two flexible joints. A first inclined portion inclines toward the rear in a downward direction and a second inclined portion inclines toward the rear in an upward direction are provided in front of and behind a lowest point of the first and second exhaust pipes, respectively, and a drive shaft for a front wheel and a steering gear box for the front wheels are disposed in front of and behind the first inclined portion, respectively.