发明授权
- 专利标题： Amide derivatives and medicinal compositions thereof
- 专利标题（中）： 酰胺衍生物及其药用组合物
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申请号： US09514637申请日： 2000-02-29
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公开(公告)号： US06177454B1公开(公告)日： 2001-01-23
- 发明人: Tatsuya Maruyama , Kenichi Onda , Masahiko Hayakawa , Takumi Takahashi , Takayuki Suzuki , Tetsuo Matsui
- 申请人： Tatsuya Maruyama , Kenichi Onda , Masahiko Hayakawa , Takumi Takahashi , Takayuki Suzuki , Tetsuo Matsui
- 优先权： JP9-10360 19970123
- 主分类号： A61K314184
- IPC分类号： A61K314184
摘要：
An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle. The symbols in the formula have the following meanings wherein A: heteroarylene; X: bond, O, S, —NR5—, —NR5CO—, —NR5CONH—, —NR5SO2— or —NR5C(═NH)NH—; R1: —H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl; R2a, R2b: —H or -lower alkyl, which may be the same or different; R3: —H or -lower alkyl; R4a, R4b: —H or —OH, which may be the same different, or R4a and R4b are taken together to form ═O or ═N—O—lower alkyl; and R5: —H or -lower alkyl.
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