发明授权
- 专利标题: Quinoline and quinazoline compounds useful in therapy
- 专利标题(中): 喹啉和喹唑啉化合物可用于治疗
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申请号: US91370申请日: 1998-06-17
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公开(公告)号: US6103738A公开(公告)日: 2000-08-15
- 发明人: Alan John Collis , David Nathan Abraham Fox , Julie Newman
- 申请人: Alan John Collis , David Nathan Abraham Fox , Julie Newman
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 优先权: GBX9526546 19951223
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61K31/495 ; A61K31/496 ; A61K31/505 ; A61K31/517 ; A61K31/535 ; A61K31/5355 ; A61K31/55 ; A61P7/00 ; A61P9/06 ; A61P9/12 ; A61P13/02 ; A61P15/00 ; C07D215/42 ; C07D239/94 ; C07D239/95 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/12 ; C07D403/14 ; C07D405/12 ; C07D405/14 ; C07D471/04 ; C07D491/04 ; C07D491/048 ; C07D491/052 ; C07D497/04 ; C07D513/04
摘要:
The invention provides compounds of formula (I), ##STR1## wherein R.sup.1 represents C.sub.1-4 alkoxy optionally substituted by one or more fluorine atoms; R.sup.2 represents H or C.sub.1-6 alkoxy optionally substituted by one or more fluorine atoms; R.sup.3 represents one or more groups independently selected from H, halogen, C.sub.1-4 alkoxy and CF.sub.3 ; in addition, R.sup.2 and one R.sup.3 group may together represent --OCH.sub.2 --, the methylene group being attached to the ortho-position of the pendant phenyl ring; R.sup.4 represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of inter alia benign prostatic hyperplasia.
公开/授权文献
- USD410857S Consumer IR thermometer 公开/授权日:1999-06-15
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