The invention provides exemplary aerosolization apparatus and methods for aerosolizing a substance. According to one exemplary method, a cartridge is coupled to a liquid dispenser and includes a substance which is in a dry state. A liquid is dispensed from the dispenser into the cartridge so that the substance may be dissolved into the dispensed liquid to form a solution. The solution is then transferred from the cartridge and onto an atomization member which is operated to aerosolize the solution.