发明授权
US5932571A Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)
{1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment
of allergic diseases
失效
用于治疗过敏性疾病的N-取代的N-甲基-N-（4-（4-（1H-苯并咪唑-2-基）{1,4}二氮杂环庚烷-1-基）-2-（芳基）丁基）苯甲酰胺
- 专利标题： Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
- 专利标题（中）： 用于治疗过敏性疾病的N-取代的N-甲基-N-（4-（4-（1H-苯并咪唑-2-基）{1,4}二氮杂环庚烷-1-基）-2-（芳基）丁基）苯甲酰胺
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申请号： US36155申请日： 1998-03-06
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公开(公告)号： US5932571A公开(公告)日： 1999-08-03
- 发明人: George D. Maynard , John M. Kane , Christopher R. Dalton , Braulio Santiago , Elizabeth M. Kudlacz , Larry D. Bratton
- 申请人： George D. Maynard , John M. Kane , Christopher R. Dalton , Braulio Santiago , Elizabeth M. Kudlacz , Larry D. Bratton
- 申请人地址： NJ Bridgewater
- 专利权人： Hoechst Marion Roussel, Inc.
- 当前专利权人： Hoechst Marion Roussel, Inc.
- 当前专利权人地址： NJ Bridgewater
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; A61K31/55
摘要：
The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)�1,4!diazepan-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
公开/授权文献
- USD367964S Picture frame 公开/授权日：1996-03-19
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