Invention Grant
- Patent Title: Process for the preparation of taxane derivatives
- Patent Title (中): 紫杉烷衍生物的制备方法
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Application No.: US962011Application Date: 1997-10-31
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Publication No.: US5861515APublication Date: 1999-01-19
- Inventor: Alain Commercon , Eric Didier , Elie Fouque
- Applicant: Alain Commercon , Eric Didier , Elie Fouque
- Applicant Address: FRX Antony
- Assignee: Rhone-Poulenc Rorer S.A.
- Current Assignee: Rhone-Poulenc Rorer S.A.
- Current Assignee Address: FRX Antony
- Priority: FRX92/11743 19921005
- Main IPC: A61K31/335
- IPC: A61K31/335 ; A61K31/337 ; A61K31/42 ; A61K31/421 ; A61P35/00 ; C07D263/04 ; C07D263/06 ; C07D305/14 ; C07D413/12
Abstract:
This invention relates to a method of preparing taxane derivatives of formula (VIII) by esterification of protected baccatin III or 10-deacetylbaccatin III by means of an acid of formula (VII), elimination of protection groupings and acylation of the amine function of the side chain. In formulae (VIII) and (VII): Ar stands for aryl, R.sub.3 is a trihalomethyl radical or phenyl substituted by a trihalomethyl radical, R.sub.4 is a hydrogen atom or is the same as R.sub.1. G.sub.1 and G.sub.2 are hydroxy protecting groups. ##STR1##
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