发明授权
- 专利标题： Modified cholera toxin based on mutagenized subunit A
- 专利标题（中）： 基于诱变亚基A的改良霍乱毒素
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申请号： US449045申请日： 1995-05-24
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公开(公告)号： US5770203A公开(公告)日： 1998-06-23
- 发明人: W. Neal Burnette , Harvey R. Kaslow
- 申请人： W. Neal Burnette , Harvey R. Kaslow
- 申请人地址： CA Thousand Oaks CA Los Angeles
- 专利权人： Amgen Inc.,University of Southern California
- 当前专利权人： Amgen Inc.,University of Southern California
- 当前专利权人地址： CA Thousand Oaks CA Los Angeles
- 主分类号： A61K39/106
- IPC分类号： A61K39/106 ; A61K39/00 ; A61P31/04 ; C07K14/00 ; C07K14/195 ; C07K14/28 ; C07K14/41 ; C07K19/00 ; C12N1/21 ; C12N15/09 ; C12N15/31 ; C12P21/02 ; C12N9/10
摘要：
The development of subunits and subunit analogs of the cholera exotoxin by recombinant DNA techniques provides vaccine products that can retain their biological activity and immunogenicity, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits result in products that retain immunogenicity, yet are reduced in, or are essentially free of, enzymatic activity associated with toxin reactogenicity.
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