发明授权
- 专利标题： Process for peptide segment condensation
- 专利标题（中）： 肽段缩合方法
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申请号： US222767申请日： 1994-04-04
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公开(公告)号： US5502165A公开(公告)日： 1996-03-26
- 发明人: Guo-Jie Ho , David A. Mathre , Zhiguo Song , Khateeta Emerson
- 申请人： Guo-Jie Ho , David A. Mathre , Zhiguo Song , Khateeta Emerson
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： B01J25/02
- IPC分类号： B01J25/02 ; C07B61/00 ; C07C231/02 ; C07C231/18 ; C07C233/00 ; C07D211/76 ; C07D295/26 ; C07D401/06 ; C07D401/14 ; C07D453/04 ; C07K1/02 ; C07K1/06 ; C07K1/10 ; C07K5/06 ; C07K5/08 ; C07K1/08
摘要：
The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in the presence of a coupling reagent and an additive. This process is useful for making ubiquitous amides and polypeptides having various biological activities.
公开/授权文献
- US4345670A Elevator control system 公开/授权日：1982-08-24
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