发明授权
US5373008A Phenylamidine and phenylguanidine derivatives and their use as
anti-diabetic agents
失效
苯脒和苯胍衍生物及其作为抗糖尿病药的用途
- 专利标题: Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents
- 专利标题(中): 苯脒和苯胍衍生物及其作为抗糖尿病药的用途
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申请号: US9807申请日: 1993-01-27
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公开(公告)号: US5373008A公开(公告)日: 1994-12-13
- 发明人: Balasubramanian Gopalan
- 申请人: Balasubramanian Gopalan
- 申请人地址: GB2
- 专利权人: The Boots Compant plc.
- 当前专利权人: The Boots Compant plc.
- 当前专利权人地址: GB2
- 优先权: GBX8903592 19890216
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; A61K31/155 ; A61K31/40 ; A61K31/4427 ; A61K31/445 ; A61K31/5375 ; A61K31/5377 ; A61P3/08 ; A61P3/10 ; C07C257/10 ; C07C257/14 ; C07C257/16 ; C07C279/18 ; C07C317/40 ; C07C317/42 ; C07C323/40 ; C07C323/41 ; C07C323/44 ; C07D207/22 ; C07D211/72 ; C07D223/12 ; C07D225/04 ; C07D233/50 ; C07D265/30 ; C07D295/13 ; C07D295/135 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; A61K31/535 ; A61K31/54 ; C07D401/10 ; C07D403/10 ; C07D413/10 ; C07D417/10
摘要:
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R.sub.1 and R.sub.2 are each aliphatic or cycloalkyl or NR.sub.1 R.sub.2 is an optionally substituted heterocyclic ring, R.sub.3 is alkyl, cycloalkyl or optionally substituted amino, R.sub.5 is an aliphatic group, R.sub.6 is H, an optionally substituted aliphatic group or a cycloalkyl group, or R.sub.3 and R.sub.5 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.5 and R.sub.6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by alkyl and R.sub.7 is optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, trifluoromethyl or cyano have utility as hypoglycemic agents.
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