Invention Grant
US5344959A Tetrahydronaphthyl and cyclopropyl substituted 1,3-butadienes having
retinoid-like activity
失效
四氢萘基和具有类视黄醇样活性的环丙基取代的1,3-丁二烯
- Patent Title: Tetrahydronaphthyl and cyclopropyl substituted 1,3-butadienes having retinoid-like activity
- Patent Title (中): 四氢萘基和具有类视黄醇样活性的环丙基取代的1,3-丁二烯
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Application No.: US63540Application Date: 1993-05-18
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Publication No.: US5344959APublication Date: 1994-09-06
- Inventor: Roshantha A. Chandraratna
- Applicant: Roshantha A. Chandraratna
- Applicant Address: CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: CA Irvine
- Main IPC: C07C13/44
- IPC: C07C13/44 ; C07C13/45 ; C07C13/47 ; C07C17/16 ; C07C22/04 ; C07C25/24 ; C07C33/30 ; C07C33/38 ; C07C45/29 ; C07C45/46 ; C07C47/238 ; C07C47/453 ; C07C49/225 ; C07C49/563 ; C07C49/792 ; C07C61/39 ; C07C69/743 ; C07C69/753 ; C07F9/54 ; C07C69/76 ; C07C63/36
Abstract:
Compounds of the formula ##STR1## wherein m is 1-4; R.sub.1 -R.sub.4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R.sub.5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R.sub.6 is hydrogen, lower alkyl, Cl, Br, I, OR.sub.11, SR.sub.11, OCOR.sub.11, SCOR.sub.11, NH2, NHR.sub.11, N(R.sub.11).sub.2, NHCOR.sub.11 OR NR.sub.11 --COR.sub.11 ; R.sub.20 is independently hydrogen or lower alkyl; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, or CR.sub.7 OR.sub.13 O, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower aklylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons, have retinoid-like activity.
Public/Granted literature
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