Invention Grant
- Patent Title: Vitamin D.sub.3 analogs
- Patent Title (中): 维生素D3类似物
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Application No.: US498062Application Date: 1990-03-23
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Publication No.: US5087619APublication Date: 1992-02-11
- Inventor: Enrico G. Baggiolini, deceased , Barbara J. Baggiolini , Bernard M. Hennessy , Shian-Jan Shiuey , Gary A. Truitt , Milan R. Uskokovic
- Applicant: Enrico G. Baggiolini, deceased , Barbara J. Baggiolini , Bernard M. Hennessy , Shian-Jan Shiuey , Gary A. Truitt , Milan R. Uskokovic
- Applicant Address: NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: NJ Nutley
- Main IPC: A61K8/67
- IPC: A61K8/67 ; A61K31/59 ; A61K31/593 ; A61Q19/00 ; C07C401/00 ; C07F7/18
Abstract:
Compounds of the formula ##STR1## wherein R is hydrogen or hydroxy, R.sub.5 is hydrogen, and A is --C.tbd.C--, ##STR2## or --CH.sub.2 --CH.sub.2 --, with the proviso that when A is --C.tbd.C--, R.sub.5 may also be deuterium, are described.The compounds of formula I are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne or seborrheic dermatitis.
Public/Granted literature
- US5636947A Watertight carrier for pneumatic tube systems Public/Granted day:1997-06-10
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