发明授权
- 专利标题: Oxadiazole derivative
- 专利标题(中): 恶二唑衍生物
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申请号: US357623申请日: 1989-05-18
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公开(公告)号: US4994478A公开(公告)日: 1991-02-19
- 发明人: Takashi Kishimoto , Takashi Okabe , Tomio Yamada , Michihiko Matsuda , Yukio Kitagawa
- 申请人: Takashi Kishimoto , Takashi Okabe , Tomio Yamada , Michihiko Matsuda , Yukio Kitagawa
- 申请人地址: JPX Tokyo
- 专利权人: Nippon Soda Co., Ltd.
- 当前专利权人: Nippon Soda Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX61-310145 19861227
- 主分类号: A01N43/82
- IPC分类号: A01N43/82 ; A01N43/836 ; A01N47/06 ; A01N47/12 ; A01N47/22 ; A01N47/24 ; C07D271/06 ; C07D271/07 ; C07D285/08 ; C07D413/04 ; C07D413/12 ; C07D417/06
摘要:
The present invention relates to a compound having the formula ##STR1## (wherein R.sub.1 denotes a phenyl radical (which may be substituted by halogen atoms, C.sub.1-6 alkyl radicals, C.sub.1-6 alkoxy radicals (which may be substituted by C.sub.1-6 alkoxy radicals,) C.sub.2-6 alkynyloxy radicals, amino radicals, nitro radicals, phenyl radicals, phenoxy radicals or C.sub.1-6 alkylthio radicals), a five or six membered heterocyclic radical (which may be substituted by halogen atoms or C.sub.1-6 alkyl radicals), a C.sub.1-6 alkyl radical (which may be substituted by aryl radicals) or ##STR2## wherein each or r.sup.1 and r.sup.2 denotes a C.sub.1-6 alkyl radical or a phenyl radical)X denotes oxygen atom or sulfur atom;A denotes ##STR3## B denotes ##STR4## D denotes ##STR5## n, m and l denote 0 or 1, (wherein r.sup.3, r.sup.4, r.sup.6, r.sup.7, r.sup.9 and r.sup.10, respectively, denotes hydrogen atom, halogen atom, C.sub.1-6 alkyl radical, the radical expressed by the formula --Y-- r.sup.12 (wherein r.sup.12 denotes hydrogen atom, cyano radical, C.sub.1-6 alkyl radical (which may be substituted by C.sub.1-6 alkoxycarbonyl radicals,) cycloalkyl radical, C.sub.1-6 alkoxycarbonyl radical, C.sub.1-6 alkylcarbamoyl radical, C.sub.1-6 alkylthiocarbamoyl radical, phenylcarbamoyl radical (which may be substituted by halogen atom), phenylthiocarbamoyl radical (which may be substituted by halogen atoms), or C.sub.1-6 alkylcarbonyl radical (which may be substituted by halogen atoms); Y denotes oxygen atom, sulfur atom, --SO--, --SO.sub.2 --, or the radical expressed by the formula ##STR6## (r.sup.13 : hydrogen atom, C.sub.1-6 alkyl radical)), or oxo-radicals or the radical expressed by the formula NOr.sup.14 where r.sup.3 or r.sup.4 ; r.sup.6 and r.sup.7 or r.sup.9 and r.sup.10 are combined (wherein r.sup.14 denotes hydrogen atom, C.sub.1-6 alkyl radical, C.sub.1-6 alkylcarbonyl radical, or C.sub.1-6 alkylcarbamoyl radical), provided, however, that r.sup.6 may form a double bond in combination with r.sup.3 or r.sup.9 ; k, k' and k" denote 0, 1 or 2, respectively;r.sup.5, r.sup.8 and r.sup.11 each denote hydrogen atom or C.sub.1-6 alkyl radical;When A is ##STR7## however, m denotes 1. Further, A and B, or B and D do not simultaneously denote oxygen atoms or sulfur atoms.)R.sub.2 denotes a phenyl radical (which may be substituted by --Z--r.sup.15 (wherein r.sup.15 denotes hydrogen atom, C.sub.1-6 alkyl radical (which may be substituted by C.sub.1-6 alkoxycarbonyl radicals or halogen atoms), phenyl radicals, cycloalkyl radicals, the pyridyl radicals (which may be substituted by halogen atoms or C.sub.1-6 haloalkyl radicals), C.sub.1-6 alkylcarbamoyl radicals, or C.sub.1-6 alkylcarbonyl radicals; Z denotes oxygen atom, sulfur atom or the radicals expressed by the formula ##STR8## (wherein r.sup.14 denotes hydrogen atom or C.sub.1-6 alkyl radical), C.sub.1-6 alkyl radicals, halogen atoms or nitro radicals), a cycloalkyl radical, a naphthyl radical, a benzthiazolyl radical (which may be substituted by C.sub.1-6 alkoxy radicals or C.sub.1-6 alkylamino radicals or halophenylamino radicals), or a C.sub.1-6 alkyl radical which may be substituted by halogen atoms);its producing processes and an acaricidal composition comprising its compound as active ingredient(s).
公开/授权文献
- US5679670A Sulfonamides useful as carbonic anhydrase inhibitors 公开/授权日:1997-10-21
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