Invention Grant
US4851541A Process for the preparation of a 4,5-tri or
tetramethylene-4-isothiazoline-3-one
失效
制备4,5-三或四亚甲基-4-异噻唑啉-3-酮的方法
- Patent Title: Process for the preparation of a 4,5-tri or tetramethylene-4-isothiazoline-3-one
- Patent Title (中): 制备4,5-三或四亚甲基-4-异噻唑啉-3-酮的方法
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Application No.: US870903Application Date: 1986-06-05
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Publication No.: US4851541APublication Date: 1989-07-25
- Inventor: Jean Maignan , Serge Restle , Michel Colin
- Applicant: Jean Maignan , Serge Restle , Michel Colin
- Applicant Address: FRX Valbonne
- Assignee: Centre International de Recherches Dermatologiques (C.I.R.D.)
- Current Assignee: Centre International de Recherches Dermatologiques (C.I.R.D.)
- Current Assignee Address: FRX Valbonne
- Priority: FRX8508469 19850605
- Main IPC: A61K31/425
- IPC: A61K31/425 ; A61K31/428 ; A61P31/04 ; A61P31/10 ; B01J27/00 ; C07C67/00 ; C07C313/00 ; C07C315/02 ; C07C317/44 ; C07C319/14 ; C07C323/41 ; C07C323/42 ; C07C323/60 ; C07C323/61 ; C07D275/04
Abstract:
A process for preparing a 4,5-tri or tetramethylene-4-isothiazoline-3-one comprises cyclizing a 2-alkyl or aralkyl thio-1-cycloalkene-1-carboxamide in the form of its sulfoxide in an organic solvent in the presence of a acid chloride and adding to the resulting 4,5-tri or tetramethylene-4-isothiazoline-3-one hydrochloride a mineral or organic base or water so as to free the 4,5-tri or tetramethylene-4-isothiazoline-3-one in the form of a free base.
Public/Granted literature
- US5903256A Method and apparatus for performing a memo function in a display system Public/Granted day:1999-05-11
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