A microsurgical irrigation/aspiration system is provided, including a controller having a pump roller head, actuators for occluding tubing, a suction sensor, and apparatus for mounting a pump cassette. The system cassette is suitable for mounting on the controller and has an opening with a pump tubing segment passing along an arcuate wall of the opening. When the cassette is mounted on the console, the roller head is engaged in the cassette opening and compresses the pump tubing segment against the arcuate wall. An infusion line passes through the cassette and is occludable by one of the actuators, and a vent line connected to the pump tubing segment is occludable by a second actuator. A suction sensing port on the cassette couples with the suction sensor in the controller.