A lifting sliding roof for a vehicle having a cover that is inserted into a cover opening and that, starting from a closed position, while lifting its rear edge, is tiltable into a tilted position and in this position is moved over the fixed part of the roof toward the rear into an open position. When the cover is lifted but rests against a front edge of the roof opening, air can flow via lateral gap areas and a rear gap area between the cover and the roof into the passenger compartment, but when the cover is tilted and is pushed to the rear at least partially, a sealing frame is provided that closes off the lateral gap areas and the rear gap area so that in this cover position, the air reaches the passenger compartment only through the area of the roof opening that is located in front of the cover.