发明授权
US4491582A N-(substituted piperazino)-1,4-dihydropyridine-3,5-carboxylic acid
失效
N-(取代的哌嗪子基)-1,4-二氢吡啶-3,5-羧酸
- 专利标题: N-(substituted piperazino)-1,4-dihydropyridine-3,5-carboxylic acid
- 专利标题(中): N-(取代的哌嗪子基)-1,4-二氢吡啶-3,5-羧酸
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申请号: US471594申请日: 1983-03-03
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公开(公告)号: US4491582A公开(公告)日: 1985-01-01
- 发明人: Bernard Loev , Howard Jones , John T. Suh
- 申请人: Bernard Loev , Howard Jones , John T. Suh
- 申请人地址: NY Tarrytown
- 专利权人: USV Pharmaceutical Corporation
- 当前专利权人: USV Pharmaceutical Corporation
- 当前专利权人地址: NY Tarrytown
- 主分类号: C07D211/90
- IPC分类号: C07D211/90 ; C07D403/06 ; A61K31/495
摘要:
1,4-Dihydropyridine carboxylic acid esters of the formula: ##STR1## wherein Ar is heteroaryl selected from the group consisting of thiophene, furan, pyridine, thiazole, pyrimidine, pyrrole, benzofuran, quinoline and benzothiophene, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydronaphthyl, or a radical of the formula ##STR2## wherein each of R.sub.5, R.sub.6 and R.sub.7 is independently H, alkyl, phenyl, tolyl, naphthyl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, methanesulfonyl, or alkylamino and R.sub.5 and R.sub.6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R.sub.1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R.sub.1 may be hydrogen; R.sub.2 is lower alkyl; and wherein N, R.sub.3 and R.sub.4 when taken together form piperazinyl; wherein the alkyl of the alkyl, carbalkoxy, alkylamino, alkoxy, alkylmercapto, alkylamino, and alkoxyalkyl contains 1-10 carbon atoms; are useful for their antihypertensive activity.
公开/授权文献
- US5172222A High definition color display device 公开/授权日:1992-12-15
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