发明授权
US4448769A Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-lactamase
inhibitor
失效
1,1-二氧代青霉烷酸酯，其用作β-内酰胺酶抑制剂
- 专利标题： Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-lactamase inhibitor
- 专利标题（中）： 1,1-二氧代青霉烷酸酯，其用作β-内酰胺酶抑制剂
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申请号： US396471申请日： 1982-07-08
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公开(公告)号： US4448769A公开(公告)日： 1984-05-15
- 发明人: Shoji Ikeda , Fumio Sakamoto , Goro Tsukamoto , Shigeru Yamabe
- 申请人： Shoji Ikeda , Fumio Sakamoto , Goro Tsukamoto , Shigeru Yamabe
- 申请人地址： JPX Tokyo
- 专利权人： Kanebo Ltd.
- 当前专利权人： Kanebo Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX56-109275 19810715; JPX56-168605 19811023
- 主分类号： C07D317/40
- IPC分类号： C07D317/40 ; C07D499/00 ; C07D499/32 ; A61K31/425
摘要：
A 1,1-dioxopenicillanic acid ester represented by formula (I) ##STR1## wherein R represents a methyl or phenyl group. The ester of formula (I) may be prepared by reacting 1,1-dioxopenicillanic acid or its salt with a compound represented by formula (III) ##STR2## wherein R is as defined above, and X represents a halogen atom, or by oxidizing a compound of formula (V) ##STR3## wherein R is as defined above. The ester of the formula (I) is useful as a .beta.-lactamase inhibitor and may be used in association with a .beta.-lactam antibiotic.
公开/授权文献
- US5785469A Working apparatus 公开/授权日：1998-07-28
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