发明授权
- 专利标题: Benzothiazocine and benzothiazonine derivatives and use
- 专利标题(中): 苯并噻嗪和苯并噻嗪衍生物和用途
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申请号: US184096申请日: 1980-09-04
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公开(公告)号: US4328238A公开(公告)日: 1982-05-04
- 发明人: Yasunobu Sato , Kuniyuki Tomita , Shinsaku Kobayashi
- 申请人: Yasunobu Sato , Kuniyuki Tomita , Shinsaku Kobayashi
- 申请人地址: JPX Tokyo
- 专利权人: Sankyo Company Limited
- 当前专利权人: Sankyo Company Limited
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX53-67368 19780605; JPX53-67369 19780605
- 主分类号: C07D281/00
- IPC分类号: C07D281/00 ; C07D281/18 ; A61K31/395 ; A61K31/55 ; C07D281/10
摘要:
Benzothiazocine and benzothiazonine derivatives of formula (I): ##STR1## in which: R.sup.1, R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom or an alkyl group;X.sup.1 and X.sup.2 are the same or different and each represents a hydrogen atom, an alkyl group, an alkoxy group, an alkanesulphinyl group, an alkanesulphonyl group, a halogen atom, a trifluoromethyl group, a nitro group or a cyano group;n is 1 or 2; andm is 0 or 1 (excluding those compounds wherein:R.sup.1, R.sup.2, R.sup.3, X.sup.1 and X.sup.2 all represent hydrogen atoms;n is 1 and m is 0; and wherein:R.sup.1 and R.sup.2 both represent hydrogen atoms;R.sup.3 represents a hydrogen atom or a methyl group;X.sup.1 represents a chlorine atom at the 9-position;X.sup.2 represents a hydrogen atom;n is 1; andm is 0)and acid addition salts thereof are novel compounds which have been found to suppress gastric secretions and are thus useful in the treatment and prevention of gastric ulcers. Compounds in which m is 0 may be prepared by reacting a corresponding .omega.-substituted thioalkylaniline derivative with a halogen or an active halogen compound and then condensing the product and, if necessary, introducing an alkyl group at the 1-position. Compounds in which m is 1 may be prepared by oxidizing the corresponding compound wherein m is 0.
公开/授权文献
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