Novel compositions for establishing environmental conditions in the human oral cavity for maintaining healthy, functional oral leucocytes, said compositions comprising a non-toxic mixture of effective amounts of: (1) at least one compound for maintaining a colloidal and viscous environment within the oral cavity which favors and promotes oral leucocyte locomotion, phagocytosis and bacterial kill; (2) at least one compound providing and maintaining a balanced ionic environment which favors and promotes locomotion, phagocytosis and bacterial kill; (3) at least one compound providing a source of energy for said oral leucocytes; and (4) at least one compound for maintaining substantially a physiological pH to promote leucocyte functions while avoiding other tissue and cell injury; and novel products and processes employing the same.