A process and integrated system for continuous monitoring of a pipeline with transported pressurized fluid that provides for continuously acquiring measurement signals emitted by at least one detection component and for processing the measurement signals by a first diagnostic method for detecting leaks of fluid and in parallel by at least one second diagnostic method; providing at least one mono or bidirectional connection between intermediate processing steps of the first diagnostic method and the at least one second diagnostic method, the connection comparing and/or transferring values associated with at least one common parameter determined or calculated by the first method or by the at least one second method, after the transfer reprocessing the measurement signals by the first diagnostic method and/or the at least one second diagnostic method or generating an alarm signal.