- 专利标题： CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
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申请号： US18770018申请日： 2024-07-11
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公开(公告)号： US20240360068A1公开(公告)日： 2024-10-31
- 发明人: Francis Johnson , Lorne Golub
- 申请人： Francis Johnson , Lorne Golub
- 申请人地址： US NY Setauket
- 专利权人： The Research Foundation for the State University of New York,Chem-Master International, Inc.
- 当前专利权人： The Research Foundation for the State University of New York,Chem-Master International, Inc.
- 当前专利权人地址： US NY Albany; US NY East Setauket
- 主分类号： C07C69/738
- IPC分类号： C07C69/738 ; C07C49/255 ; C07C225/22 ; C07C235/78 ; C07C235/80 ; C07C237/20 ; C07D213/50 ; C12N9/64
摘要：
This invention provides a compound having the structure
wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.
wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.
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