A system and method for predictive analysis of Seawater Reverse Osmosis (SWRO) desalination plants receives first data associated with a SWRO plant, including a first set of parameters associated with seawater, a second set of parameters associated with a permeate, and a third set of parameters associated with a brine. The system determines a fourth set of parameters by applying normalization techniques to the received first data. The system determines, based upon the fourth set of parameters, a set of membrane performance parameters associated with the SWRO plant, or a set of diagnostic indicators associated with at least one of the SWRO plant and the seawater. The system outputs the determined set of membrane performance parameters or the set of diagnostic indicators.