- 专利标题： COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
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申请号： US18260096申请日： 2021-12-30
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公开(公告)号： US20240309366A1公开(公告)日： 2024-09-19
- 发明人: Ramón Díaz TRELLES , Kiyoshi TACHIKAWA , Priya Prakash KARMALI , Rajesh MUKTHAVARAM , Padmanabh CHIVUKULA , José María MORENO-NAVARRETE , Aleix Gavaldá NAVARRO , José Manuel FERNÁNDEZ-REAL , Marta Giralt OMS , Francesc Villarroya GOMBAU
- 申请人： Arcturus Therapeutics, Inc. , CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. , INSTITUT D’INVESTIGACIÓ BIOMÉDICA DE GIRONA DR JOSEP TRUETA , UNIVERSITAT DE BARCELONA
- 申请人地址： US CA San Diego
- 专利权人： Arcturus Therapeutics, Inc.,CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P.,INSTITUT D’INVESTIGACIÓ BIOMÉDICA DE GIRONA DR JOSEP TRUETA,UNIVERSITAT DE BARCELONA
- 当前专利权人： Arcturus Therapeutics, Inc.,CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P.,INSTITUT D’INVESTIGACIÓ BIOMÉDICA DE GIRONA DR JOSEP TRUETA,UNIVERSITAT DE BARCELONA
- 当前专利权人地址： US CA San Diego
- 国际申请： PCT/US21/65757 2021.12.30
- 进入国家日期： 2023-06-30
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K9/51 ; A61K31/713 ; A61P3/04
摘要：
Provided herein are compositions and methods for treating metabolic disorders, such as hepatic steatosis, adipose tissue dysfunction, and insulin resistance. Small interfering RNAs (siRNAs) targeting LPS-binding protein (LBP) that include unlocked nucleotides (UNA) and their therapeutic applications for the treatment of metabolic disorders are provided herein.
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