A safe injection system includes an injection system body defining a proximal opening at a proximal end thereof, an injection system body interior, and a needle attachment interface at a distal end thereof. The system also includes a stopper member disposed in the injection system body interior. The system further a plunger member configured to be manipulated to insert the stopper member relative to the injection system body. Moreover, the system includes a needle hub assembly coupled to the needle attachment interface. The needle hub assembly includes a needle hub defining a latch space in a distal end thereof, a needle latch defined by the needle hub in the latch space, and a needle removably coupled to the needle hub by the needle latch.