Invention Publication
- Patent Title: TRANSFECTED T-CELLS AND T-CELL RECEPTORS FOR USE IN IMMUNOTHERAPY AGAINST CANCERS
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Application No.: US18581947Application Date: 2024-02-20
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Publication No.: US20240279308A1Publication Date: 2024-08-22
- Inventor: Dominik MAURER , Sebastian BUNK , Leonie ALTEN
- Applicant: IMMATICS BIOTECHNOLOGIES GMBH
- Applicant Address: DE Tuebingen
- Assignee: IMMATICS BIOTECHNOLOGIES GMBH
- Current Assignee: IMMATICS BIOTECHNOLOGIES GMBH
- Current Assignee Address: DE Tuebingen
- Priority: GB 04492.7 2016.03.16
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61K35/12 ; A61K35/17 ; A61K35/66 ; A61K38/00 ; C07K14/435 ; C12N15/09 ; C12N15/10

Abstract:
Disclosed are T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as MAG-003 have the amino acid sequence of KVLEHVVRV (SEQ ID NO:1). The description further relates to peptides, proteins, nucleic acids, cells for use in immunotherapeutic methods, the immunotherapy of cancer, and tmor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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