Invention Publication
- Patent Title: METHOD FOR THE FERMENTATIVE PRODUCTION OF L-LYSINE USING C. GLUTAMICUM STRAINS EXPRESSING MODIFIED GLUCONATE REPRESSOR PROTEINS GNTR1 AND GNTR2
-
Application No.: US18693613Application Date: 2022-09-09
-
Publication No.: US20240271169A1Publication Date: 2024-08-15
- Inventor: Silke Jerrentrup , Brigitte Bathe , Kornelia Voß , Frank Jankowitsch
- Applicant: Evonik Operations GmbH
- Applicant Address: DE Essen
- Assignee: Evonik Operations GmbH
- Current Assignee: Evonik Operations GmbH
- Current Assignee Address: DE Essen
- Priority: EP 197722.8 2021.09.20
- International Application: PCT/EP2022/075068 2022.09.09
- Date entered country: 2024-03-20
- Main IPC: C12P13/08
- IPC: C12P13/08 ; C07K14/34 ; C12N9/12

Abstract:
C. glutamicum strains express modified gluconate repressor proteins GntR1 and GntR2. The C. glutamicum strains have an increased ability to produce L-lysine compared with an ability of a wildtype strain. The gluconate repressor protein GntR1 includes an amino acid sequence of SEQ ID NO: 9, where the amino acid Arg in position 102 is replaced by the amino acid Glu. The gluconate repressor protein GntR2 includes SEQ ID NO: 10, and its activity is attenuated compared to the activity of the GntR2 repressor protein of the wild-type strain. A method is developed for the fermentative production of L-lysine using such C. glutamicum strains.
Information query