A refrigeration system includes a heat exchanger including a gas cooler or condenser. The heat exchanger includes a heat exchanger inlet and a heat exchanger outlet. The refrigeration system further includes an evaporator including an evaporator inlet and an evaporator outlet. The refrigeration system further includes a compressor including a compressor inlet fluidly coupled to the evaporator outlet and a compressor outlet fluidly coupled to the heat exchanger inlet. The refrigeration system further includes a pressure exchanger (PX) including a first PX inlet fluidly coupled to the heat exchanger outlet, a first PX outlet fluidly coupled to the heat exchanger inlet, a second PX inlet fluidly coupled to the evaporator outlet, and a second PX outlet fluidly coupled to the evaporator inlet.