Invention Publication
- Patent Title: SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
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Application No.: US18588930Application Date: 2024-02-27
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Publication No.: US20240254541A1Publication Date: 2024-08-01
- Inventor: Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
- Applicant: The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
- Applicant Address: US MA Boston
- Assignee: The Children's Medical Center Corporation,The United States of America, As Represented by the Secretary, Department of Health & Human Services
- Current Assignee: The Children's Medical Center Corporation,The United States of America, As Represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US MA Boston; US MD Bethesda
- Main IPC: C12Q1/6827
- IPC: C12Q1/6827 ; C12N9/10 ; C12Q1/26 ; C12Q1/6806 ; C12Q1/6869 ; G01N33/53
Abstract:
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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