A sample collection device includes a housing extending from a mouthpiece end to an air outlet end, the housing defining an airflow channel from the mouthpiece end to the air outlet end, the mouthpiece end configured to receive an exhalation airflow. A porous sample collection media is fixed within the housing and along the airflow channel. A mouthpiece end cap is replaceably coupled to the mouthpiece end and an air outlet end cap is replaceably coupled to the air outlet end.