Invention Publication
- Patent Title: CRISPR-CAS3 SYSTEMS FOR TARGETED GENOME ENGINEERING
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Application No.: US18563175Application Date: 2022-05-26
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Publication No.: US20240229081A1Publication Date: 2024-07-11
- Inventor: Yan Zhang , Zhonggang Hou , Renke Tan , Ailong Ke
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CORNELL UNIVERSITY
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,CORNELL UNIVERSITY
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,CORNELL UNIVERSITY
- Current Assignee Address: US MI Ann Arbor
- International Application: PCT/US22/31091 2022.05.26
- Date entered country: 2023-11-21
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N9/22 ; C12N15/11
Abstract:
The present disclosure provides systems and methods of altering a nucleic acid sequence, which comprise an engineered Type I CRISPR/Cas system comprising Cas3 and Cas11. Particularly. the system and methods described herein use compact engineered CRISPR-Cas3 systems (e.g., Type I-C, Type I-B, or Type I-D) for genetic manipulations (e.g., in eukaryotic cells).
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