A computer-implemented method includes receiving an encoding table defining a plurality of mappings between input segments and encoded segments, where each encoded segment defines an ordered string of data representing a sequence of one or more deoxyribonucleic acid (DNA) nucleotide bases; identifying an input string of input data; segmenting the input string into a plurality of input tuples; for each input tuple, generate a plurality of encoded tuples by identifying an entry of the encoding table that has an input segment equal to the input tuple and adding an encoded tuple that includes an encoded segment; converting the plurality of encoded tuples into a DNA sequence string of DNA nucleotides by concatenating the plurality of encoded tuples in an order defined by the plurality of input tuples; and transmitting the DNA sequence string of DNA nucleotides to be used for synthesizing at least one DNA molecule.