- 专利标题: GLYCOSIDE PRODUCT BIOSYNTHESIS AND RECOVERY
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申请号: US18038067申请日: 2021-11-24
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公开(公告)号: US20240093258A1公开(公告)日: 2024-03-21
- 发明人: Ajikumar PARAYIL KUMARAN , Christine Nicole S. SANTOS , Jason DONALD , Aaron LOVE , Yiying ZHENG , Adel GHADERI , Vineet SHASTRY , Lu CHEN , Christopher TOOMEY , Hannah LYNCH , Eric NIEMINEN
- 申请人: Manus Bio Inc.
- 申请人地址: US MA Waltham
- 专利权人: Manus Bio Inc.
- 当前专利权人: Manus Bio Inc.
- 当前专利权人地址: US MA Waltham
- 国际申请: PCT/US21/60722 2021.11.24
- 进入国家日期: 2023-05-22
- 主分类号: C12P19/60
- IPC分类号: C12P19/60 ; C12N9/10 ; C12N9/90
摘要:
In various aspects and embodiments, the present disclosure provides methods for making glycosylated products, as well as bacterial cells and uridine diphosphate (UDP)-dependent glycosyltransferase (UGT) enzymes useful for the same. In other aspects and embodiments, the disclosure provides methods for high yield and/or high purity recovery of such glycoside products from microbial cultures or cell free reactions. In various aspects and embodiments, the disclosure provides for whole cell bioconversion processes involving the glycosylation of a desired substrate, and/or the recovery of the glycosylated product at high yield and/or high purity.
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