This disclosure relates to an engineered a novel synthetic artificial stem cell (SASC) system which mimics the paracrine effect of the stem cell secretome and provides tailorability of the composition for targeted tissue regeneration. This novel SASC system demonstrates the feasibility of developing a completely synthetic, tailorable stem cell secretome which reinforces the possibility of developing a new therapeutic strategy that provides better control over targeted tissue engineering applications. Disclosed herein are biodegradable polymeric microspheres that have been used to encapsulate secretome active agents. These microspheres mimic or have the potential to result in a greater therapeutic paracrine effect compared to stem cells, without the added risk of immunological response or the extra pro-inflammatory, antagonistic or inert factors/cytokines. The compositions may be personalized to any disease and/or individual, therefore, adding a much needed element to therapeutics.