A tube with an integrated cleanout port includes a medical-grade tube, a suction adaptor, and a check valve, The medical-grade tube that connect between the patient's endotracheal tube and the Y-pipe of the mechanical ventilator includes a tubular body, a first connector end, and a second connector end. The suction adaptor is laterally positioned to the tubular body and hermetically connected to the tubular body that may be corrugated or not corrugated. The check valve is hermetically connected within the suction adaptor, wherein the tubular body is in fluid communication with the suction adaptor through the check valve. Due to the configuration of the check valve, any fluid buildup such as condensation, sputum, blood, and mucous within the tubular body can easily be removed via the suction adaptor without having to shut off the mechanical ventilator or break the circuit which could potentially cause harm to the patient.