Provided herein are packaging systems suitable for storing products, such as food products. The packaging systems are made up of multilayer film constructions that provide controlled release of an active agent at a point in time that is past the manufacturing of the packaging systems but coincides with their functional use (e.g., at the food packaging step). The multilayer film constructions have a composition that is sensitive to humidity, which converts the constructions from a barrier to a transmitter of the active agent loaded within multilayer film constructions.