A tire pressure detection system with separated antennas includes a detection end and a receiving end. The detection end includes tire pressure detectors to detect the tire to obtain the information of tire status. The tire pressure detectors output the information of the tire status in the form of radio frequency signal and Bluetooth signal. In addition to the transmission to the built-in tire-pressure receiving device, the information of the tire status also can be displayed on the in-vehicle audio-video device and the user's mobile device.