Critical infrastructure (CI) blueprint selection for optimized response to state changing conditions includes defining a hierarchy of interdependent CI elements of a community in a digital twin and receiving characterization data for different nodes of the digital twin. A fingerprint is generated for the hierarchy based upon the characterization and a blueprint which corresponds to the fingerprint retrieved from a data store, the blueprint defining a set of parameters to be applied to different computing elements of different nodes in the hierarchy determined to minimize a cascading effect of a state changing condition in one of the nodes. Finally, the set of parameters of the retrieved blueprint is applied to corresponding computing elements of the digital twin and a state changing condition is simulated in the digital twin in a selected node so as to compute the cascading effect of the state changing condition to other nodes dependent upon the selected node.