Systems and methods for dynamically reprioritizing pick jobs in a fulfillment center are described herein. The example systems can be configured to periodically classify pick jobs in order to optimize throughput of the fulfillment center. The classifying can include determining an estimated completion time for pick jobs and identifying at-risk jobs that may complete after their associated due dates. The at-risk jobs can be assigned to autonomous vehicles based primarily on their associated due dates. Other pick jobs that are not at-risk can be assigned to autonomous vehicles based primarily on efficiency. The at-risk pick jobs can be assigned to autonomous vehicles before the other pick jobs.